Genesearch Neuroscience Resources

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This video showcases a whole mouse brain prepared with tissue clearing techniques to make it transparent, and stained with a monoclonal antibody to detect β-Amyloid, a hallmark of neurodegeneration in Alzheimer’s disease. 

Read the Cell Signaling Technology blog post to learn more about tissue clearing techniques, or view validation data and citations for the antibody used in this study, β-Amyloid (D54D2) XP® Rabbit mAb #8243.

Hallmarks of Neurodegeneration

Neurodegenerative diseases are characterized by a loss of neuronal structure and function that leads to problems with movement (ataxis) or mental function (dementia). These changes occur due to genetic mutations or protein folding disorders that can accumulate with age. While pathophysiologies like amyloid plaques are well documented, many of the cellular processes that drive neurodegeneration have yet to be fully elucidated. Defects in these key processes may be shared among different neurodegenerative diseases, making it likely that new therapies targeting one process may alleviate the progression of many conditions.

Cell Signaling Technology have put together a starter’s guide on the cellular mechanisms that drive neurodegeneration in diseases such as Alzheimer’s Disease, Parkinson’s Disease, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington’s Disease. Wondering how to identify the many different cell types that make up the Central Nervous System (CNS)? They also have a Cell Type Marker Guide!

Neuroscience signaling pathways

CST signaling pathway diagrams allow you to click on individual nodes to find research resources or product information. You can also download the pathway diagrams for educational and research purposes.

G-Protein-Coupled Receptors Signaling to MAPK/Erk

Dopamine Signaling in Parkinson’s Disease

TREM2 Signaling

Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer’s Disease

Neuronal and Glial Cell Markers

Vesicle Trafficking Presynaptic Signaling

Post-Synaptic Signaling