Glycolysis and lactate metabolism are central to cellular energy production and metabolic adaptation. Changes in these pathways are particularly important in rapidly proliferating cells and are widely investigated in cancer, metabolism and cell biology research.
Key proteins including PKM2, LDHA, MCT1 and MCT4 regulate the production, utilisation and transport of pyruvate and lactate. Studying these targets can provide valuable insight into altered cellular metabolism and the mechanisms cells use to maintain energy production under changing conditions.
ABclonal provides validated antibodies targeting important components of the glycolysis and lactate metabolism pathways, including the products highlighted below.
PKM2 is a pyruvate kinase involved in glycolysis and catalyses the conversion of phosphoenolpyruvate to pyruvate while generating ATP. Its role at a key metabolic junction makes PKM2 an important target in studies of glycolytic activity and cellular metabolism.
Featured antibody: PKM2-specific Rabbit monoclonal antibody A20991.
LDHA is closely associated with lactate metabolism and is frequently studied alongside glycolytic pathways. Investigation of LDHA expression can help researchers examine changes in metabolic state and the relationship between pyruvate and lactate metabolism.
Featured antibody: KD Validated LDHA Rabbit monoclonal antibody A28205.
Lactate metabolism also depends on the movement of monocarboxylates across cell membranes. MCT1 (SLC16A1) and MCT4 (SLC16A3) are important targets for researchers studying lactate transport and metabolic adaptation.
ABclonal’s featured antibodies for these targets are MCT1/Monocarboxylic acid transporter 1 Rabbit mAb A28999 and SLC16A3/MCT4 Rabbit mAb A27772.
Combining markers of glycolysis, lactate production and lactate transport provides researchers with a broader view of cellular metabolic activity. Targets such as PKM2, LDHA, MCT1 and MCT4 are therefore useful components of research into metabolic regulation, tumour metabolism and cellular responses to changing energy demands.
Genesearch supplies ABclonal research antibodies to Australian laboratories. Browse the Genesearch catalogue or contact us using the details at the top or bottom of this page if you require product information, pricing or assistance selecting antibodies for your research.
Search the Genesearch catalogue or speak with us about ABclonal antibodies for your research.
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